| Experimental Group |
Midazolam |
Midazolam, maximum dose: 0.05mg/kg, by bolus of 1mg every 5 min (not to exceed 5 mg), by IV injection (through a peripheral venous line).
Dilution: 1 ampoule of midazolam (1cc) in 4cc of isotonic saline solution [1cc=1mg].
|
duration of the bronchoscopy |
The study consisted of the use of midazolam for sedation during bronchoscopy performed for a specific indication according to the following steps:
1) Midazolam, maximum dose: 0.05mg/kg, by bolus of 1mg every 5 min (not to exceed 5 mg), by IV injection (through a peripheral venous line).
2) Per physician trained in resuscitation and dedicated to sedation.
3) Two assistants, including one person with a nursing diploma, who assisted the physician performing the examination, to ensure safety in case of problems during the examination.
4) Resuscitation equipment must be available.
5) Flumazenil (Anexate) nearby (to be used in case of severe depression of the central nervous system with respect to its contraindications)
6) An isotonic saline solution nearby.
7) Patient scoped with monitoring of vital parameters (SpO2, Blood pressure, Pulse...).
8) MOASS score noted every 5 min (appendix 3).
9) Dose and time of midazolam injection noted with maximum dose respected and total dose administered noted.
10) Intra- and post-procedural monitoring written down and traced (patient scoped).
11) Discharge criteria from the interventional room identical to those of the recovery room (MOASS score>=5, oxygen weaning...) with a 3-hour monitoring.
12) Post-procedure advice identical to the ambulatory GA: No driving, not be alone andno activity with responsibility (childcare, elderly, important appointments...)in the 12 hours that follow,
13) The duration, the end-time of the bronchoscopy and thedischarge-time noted.
|
46 |
|
| Control Group |
Placebo |
Isotonic saline solution
every 5 min, by IV injection (through a peripheral venous line).
|
During the bronchoscopy |
Isotonic saline solution
Resuscitation equipment must be available.
An isotonic saline solution nearby.
Patient scoped with monitoring of vital parameters (SpO2, Blood pressure, Pulse...).
Intra- and post-procedural monitoring written down and traced (patient scoped).
The duration, the end-time of the bronchoscopy and the discharge-time noted.
|
47 |
Placebo |