Trial no.:
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PACTR201801003005742 |
Date of Approval:
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24/01/2018 |
Trial Status:
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Retrospective registration - This trial was registered after enrolment of the first participant |
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TRIAL DESCRIPTION |
Public title
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Gravity assisted continuous flow peritoneal dialysis in children with acute renal failure |
Official scientific title |
Gravity assisted continuous flow peritoneal dialysis in children with acute renal failure |
Brief summary describing the background
and objectives of the trial
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Peritoneal dialysis (PD)is still the most commonly used form of dialysis used in acute kidney injury worldwide in children. Specifically, in low to middle income countries where it is often the only form of dialysis available for children with acute kidney injury. One of the criticisms of PD is the lower clearance (toxin removal) and ability for ultrafiltration (taking fluid off the patient)These issues may become important in certain cases of acute renal failure. Continuous flow peritoneal dialysis(CFPD) is a way of doing peritoneal dialysis where instead of the fluid being allowed to dwell in the peritoneal cavity and then intermittently removed, it is allowed to flow continuously through the peritoneal cavity by using two peritoneal dialysis catheters. In this way diffusion gradients are optimised and dialysis time is increased. We developed a novel technique over the past few years at Red Cross Children¿s hospital of doing CFPD in children with acute renal failure. This was very effective and vastly increasing clearance and ultrafiltration. These studies have been published in the international literature. The technique we used involved high speed pumps to drive the fluid. These pumps are expensive and so limited this technique being rolled out into low income countries where it would be the most useful. In this current study we will use a technique of CFPD using just low cost tubing and fluid and just gravity to drive fluid flow. This technique has been extensively tested in vitro an shown to be safe. Our primary objectives in this study will be compare CFPD to conventional PD in terms of efficacy complications and costs in children with acute kidney injury. The study design is a prospective randomized cross-over study.
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Type of trial |
RCT |
Acronym (If the trial has an acronym then please provide) |
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Disease(s) or condition(s) being studied |
Acute kidney injury,Injury, Occupational Diseases, Poisoning,Kidney Disease,Paediatrics |
Sub-Disease(s) or condition(s) being studied |
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Purpose of the trial |
Treatment: Other |
Anticipated trial start date |
01/02/2018 |
Actual trial start date |
01/01/2018 |
Anticipated date of last follow up |
01/02/2020 |
Actual Last follow-up date |
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Anticipated target sample size (number of participants) |
20 |
Actual target sample size (number of participants) |
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Recruitment status |
Not yet recruiting |
Publication URL |
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