Pan African Clinical Trials Registry
South African Medical Research Council, South African Cochrane Centre
PO Box 19070, Tygerberg, 7505, South Africa
Telephone: +27 21 938 0506 / +27 21 938 0834 Fax: +27 21 938 0836
Email: pactradmin@mrc.ac.za Website: pactr.samrc.ac.za
Trial no.: PACTR202604832502233 Date of Registration: 22/04/2026
Trial Status: Retrospective registration - This trial was registered after enrolment of the first participant
TRIAL DESCRIPTION
Public title Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in Anterior Cruciate Ligament Reconstructive Surgery
Official scientific title Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in Anterior Cruciate Ligament Reconstructive Surgery, A Prospective Randomized Double-Blind Study
Brief summary describing the background and objectives of the trial Background: Anterior cruciate ligament (ACL) reconstruction is frequently associated with moderate-to-severe postoperative pain that may hinder early mobilization and recovery. Motor-sparing regional techniques have gained increasing attention as part of multimodal analgesia. This study aimed to compare the analgesic efficacy of adductor canal block (ACB), infiltration between the popliteal artery and capsule of the knee (IPACK), and genicular nerve block (GNB) in patients undergoing ACL reconstruction.
Type of trial RCT
Acronym (If the trial has an acronym then please provide) Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in ACLR
Disease(s) or condition(s) being studied Anaesthesia
Sub-Disease(s) or condition(s) being studied
Purpose of the trial compare the analgesic efficacy of adductor canal block (ACB), infiltration between the popliteal artery and capsule of the knee (IPACK), and genicular nerve block (GNB) in patients undergoing ACL reconstruction.
Anticipated trial start date 13/05/2024
Actual trial start date
Anticipated date of last follow up 04/05/2026
Actual Last follow-up date
Anticipated target sample size (number of participants) 60
Actual target sample size (number of participants)
Recruitment status Closed to recruitment,follow-up continuing
Publication URL Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in Anterior Cruciate Ligament Reconstructive Surgery, A Prospective Randomized Double-Blind Study
Secondary Ids Issuing authority/Trial register
52024ANET27 Faculty of Medicine Menoufia university
STUDY DESIGN
Intervention assignment Allocation to intervention If randomised, describe how the allocation sequence was generated Describe how the allocation sequence/code was concealed from the person allocating the participants to the intervention arms Masking If masking / blinding was used
Parallel: different groups receive different interventions at same time during study Randomised Simple randomization using a randomization table created by a computer software program Sealed opaque envelopes Masking/blinding used Outcome Assessors,Participants
INTERVENTIONS
Intervention type Intervention name Dose Duration Intervention description Group size Nature of control
Control Group ACB group 20 mL of 0.25% bupivacaine 24 hours postoperatively After GA induction, an ultrasound-guided adductor canal block 20 Active-Treatment of Control Group
Experimental Group IPACK group 20 ml solution of 0.25% bupivacaine 24 postoperative hours After GA induction, infiltration under ultrasonic guidance between the popliteal artery and femur. The infiltration will commence 2 cm distal to the popliteal artery and will be gradually withdrawn while infiltrating proximally. 20
Experimental Group GNB group 20 ml of 0.25% bupivacaine 24 postoperative hours After GA induction, ultrasound-guided infiltration targets the superomedial, superolateral, and inferomedial genicular nerves 20
ELIGIBILITY CRITERIA
List inclusion criteria List exclusion criteria Age Category Minimum age Maximum age Gender
ASA physical status I-II, of both sexes, aged 18-60 years, Scheduled for ACL reconstruction with a Hamstring graft from the same limb • Peroneous longus graft or adductor policis graft from the same limb. • Any type of graft from the other limb. • Severe cardiovascular diseases. • Significant neurological or psychiatric disorders • Patients with a history of coagulopathy or bleeding disorder. • Allergic to local anesthetics. • Injection site infection. • History of drug addiction. • Chronic opioid use. • Pregnant or suspected pregnancy Adult: 18 Year(s)-44 Year(s),Middle Aged: 45 Year(s)-64 Year(s) 18 Year(s) 60 Year(s) Both
ETHICS APPROVAL
Has the study received appropriate ethics committee approval Date the study will be submitted for approval Date of approval Name of the ethics committee
Yes 08/05/2024 Menoufia University Faculty of Medicine Research Ethics Committee
Ethics Committee Address
Street address City Postal code Country
Yassin Abdel Ghaffar St. , branching off from Gamal Abdel Nasser St Shebin ElKom 32511 Egypt
OUTCOMES
Type of outcome Outcome Timepoint(s) at which outcome measured
Primary Outcome Postoperative VAS pain scores at 1, 2, 4, 8, 12, and 24 hours postoperatively
Secondary Outcome Time for first call for rescue analgesia postoperative 24 h
Secondary Outcome supplemented fentanyl required Intraoperative
Secondary Outcome Hemodynamic parameters (HR and MAP). Intraoperative and postoperative
Secondary Outcome Intraoperative and postoperative hemodynamic parameters (HR and MAP). first 24 hours after surgery
RECRUITMENT CENTRES
Name of recruitment centre Street address City Postal code Country
Menoufia University Faculty of Medicine Research Ethics Committee Yassin Abdel Ghaffar St. , branching off from Gamal Abdel Nasser St Shebin ElKom 32511 Egypt
FUNDING SOURCES
Name of source Street address City Postal code Country
Alaa Eldin Abdel Sami Aiad Yassin Abdel Gaffar st, branching off from Abdel Nasser st Shebin ElKom 32511 Egypt
SPONSORS
Sponsor level Name Street address City Postal code Country Nature of sponsor
Primary Sponsor Alaa Eldin Abdel Sami Aiad Yassin Abdel Gaffar st, branching off from Abdel Nasser st Shebin ElKom 32511 Egypt Individual
COLLABORATORS
Name Street address City Postal code Country
CONTACT PEOPLE
Role Name Email Phone Street address
Principal Investigator Alaa Eldin Aiad alaa222aiad@gmail.com +201012343971 Yassin Abdel Gaffar st, branching off from Abdel Nasser st
City Postal code Country Position/Affiliation
Shebin ELKom 32511 Egypt Assistant Professor of Anesthesiology
Role Name Email Phone Street address
Public Enquiries Sadek Sadek sadek@med.menofia.edu.eg +201006878214 Yassin Abdel Gaffar st, branching off from Abdel Nasser st
City Postal code Country Position/Affiliation
Shebin El Kom 32511 Egypt Assistant Professor of Anesthesiology
Role Name Email Phone Street address
Scientific Enquiries Amany Sultan amanysultan@med.menofia.edu.eg +201099404550 Yassin Abdel Gaffar st, branching off from Abdel Nasser st
City Postal code Country Position/Affiliation
Shebin El Kom 32511 Egypt Lecturer of anesthesiology
REPORTING
Share IPD Description Additional Document Types Sharing Time Frame Key Access Criteria
Yes All individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices Study Protocol Immediately following publication, no end date Not applicable
URL Results Available Results Summary Result Posting Date First Journal Publication Date
Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in Anterior Cruciate Ligament Reconstructive Surgery, A Prospective Randomized Double-Blind Study No
Result Upload 1: Result Upload 2: Result Upload 3: Result Upload 4: Result Upload 5:
Result URL Hyperlinks Link To Protocol
Result URL Hyperlinks
Changes to trial information
Section Name Field Name Date Reason Old Value Updated Value
Trial Information Public title 17/04/2026 new simple title Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in Anterior Cruciate Ligament Reconstructive Surgery, A Prospective Randomized Double-Blind Study Adductor Canal, IPACK, and Genicular Nerve Blocks for Analgesia in Anterior Cruciate Ligament Reconstructive Surgery
Section Name Field Name Date Reason Old Value Updated Value
Trial Information Trial phase 17/04/2026 we compare 3 regional techniques, not for the first time in human Phase-1 Not Applicable
Section Name Field Name Date Reason Old Value Updated Value
Ethics Ethics List 21/04/2026 New ethics approval letter more proportional TRUE, Menoufia University Faculty of Medicine Research Ethics Committee, Yassin Abdel Ghaffar St. , branching off from Gamal Abdel Nasser St, Shebin ElKom, 32511, Egypt, , 08 May 2024, +2482223964, info.med@med.menoufia.edu.eg, 41153_38387_4737.pdf TRUE, Menoufia University Faculty of Medicine Research Ethics Committee, Yassin Abdel Ghaffar St. , branching off from Gamal Abdel Nasser St, Shebin ElKom, 32511, Egypt, , 08 May 2024, +2482223964, info.med@med.menoufia.edu.eg, 41153_38387_4737.pdf
Section Name Field Name Date Reason Old Value Updated Value
Ethics Ethics List 17/04/2026 first one is disproportial TRUE, Menoufia University Faculty of Medicine Research Ethics Committee, Yassin Abdel Ghaffar St. , branching off from Gamal Abdel Nasser St, Shebin ElKom, 32511, Egypt, , 08 May 2024, +2482223964, info.med@med.menoufia.edu.eg, 41153_38387_4737.pdf TRUE, Menoufia University Faculty of Medicine Research Ethics Committee, Yassin Abdel Ghaffar St. , branching off from Gamal Abdel Nasser St, Shebin ElKom, 32511, Egypt, , 08 May 2024, +2482223964, info.med@med.menoufia.edu.eg, 41153_38387_4737.pdf