Pan African Clinical Trials Registry
South African Medical Research Council, South African Cochrane Centre
PO Box 19070, Tygerberg, 7505, South Africa
Telephone: +27 21 938 0835 or +27 21 938 0967
Email: pactradmin@mrc.ac.za Website: pactr.samrc.ac.za
Trial no.: PACTR202607862657055 Date of Registration: 31/07/2026
Trial Status: Registered in accordance with WHO and ICMJE standards
TRIAL DESCRIPTION
Public title Effectiveness of a structured chair-based exercise intervention on blood pressure control among desk-based workers with hypertension in southern Nigeria: a randomized controlled trial
Official scientific title EFFECTIVENESS OF A STRUCTURED CHAIR-BASED EXERCISE INTERVENTION ON BLOOD PRESSURE CONTROL AMONG DESK-BASED WORKERS WITH HYPERTENSION IN SOUTHERN NIGERIA: A RANDOMIZED CONTROLLED TRIAL
Brief summary describing the background and objectives of the trial Hypertension remains a major global public health challenge and a leading modifiable risk factor for cardiovascular morbidity and mortality. Increasing urbanization and the growing prevalence of sedentary occupations have contributed substantially to poor blood pressure control, particularly among desk-based workers who spend prolonged hours sitting. Sedentary behaviour has been associated with adverse cardiometabolic outcomes, including endothelial dysfunction, obesity, insulin resistance, and elevated blood pressure. Although workplace physical activity interventions have shown potential cardiovascular benefits, evidence regarding the effectiveness of structured chair-based exercise interventions among hypertensive adults in low-resource African settings remains limited. Aim To evaluate the effectiveness of a structured chair-based exercise intervention on blood pressure control among adults with desk-bound jobs in southern Nigeria and identify simple measures to reduce sedentary behavior and hypertension. Objectives 1. To compare the mean change in systolic and diastolic blood pressure between the intervention and control groups over the study period. 2. To assess the effect of the structured chair-based exercise intervention on the proportion of participants achieving controlled blood pressure. 3. To evaluate adherence to the structured chair-based exercise intervention among participants in the intervention group. 4. To assess the effect of the intervention on secondary cardiovascular risk indicators (e.g., heart rate, body mass index or WC/ WHR).
Type of trial RCT
Acronym (If the trial has an acronym then please provide)
Disease(s) or condition(s) being studied Cardiology,Circulatory System,Mental and Behavioural Disorders
Sub-Disease(s) or condition(s) being studied
Purpose of the trial Physical activity and nutrition
Anticipated trial start date 02/06/2026
Actual trial start date
Anticipated date of last follow up 31/12/2026
Actual Last follow-up date
Anticipated target sample size (number of participants) 218
Actual target sample size (number of participants)
Recruitment status Not yet recruiting
Publication URL
Secondary Ids Issuing authority/Trial register
STUDY DESIGN
Intervention assignment Allocation to intervention If randomised, describe how the allocation sequence was generated Describe how the allocation sequence/code was concealed from the person allocating the participants to the intervention arms Masking If masking / blinding was used
Parallel: different groups receive different interventions at same time during study Randomised Simple randomization using a randomization table created by a computer software program Sealed opaque envelopes Open-label(Masking Not Used)
INTERVENTIONS
Intervention type Intervention name Dose Duration Intervention description Group size Nature of control
Experimental Group Chair based exercise Each exercise will be performed for one minute, giving a total exercise duration of approximately five minutes per session. Participants will be instructed to perform the exercise routine every 60 minutes during working hours over an average 8-hour workday, amounting to approximately 40 minutes of daily physical activity. The study intervention will last for 3 months while participants will be followed up for six months, with assessments conducted at baseline, 3 months, and 6 months. Participants in the intervention arm will receive standard hypertension care in addition to a structured chair-based exercise programme designed for workplace implementation. The exercise programme will consist of five chair-based exercises: • Seated marching • Knee extensions • Seated calf raises • Seated torso rotations • Seated jumping jacks Each exercise will be performed for one minute, giving a total exercise duration of approximately five minutes per session. Participants will be instructed to perform the exercise routine every 60 minutes during working hours over an average 8-hour workday, amounting to approximately 40 minutes of daily physical activity. The intervention will be delivered through: 1. An initial supervised demonstration session, 2. Printed instructional materials, 3. Weekly reminder messages via WhatsApp or SMS, 4. Monthly reinforcement sessions during clinic visits. Exercise intensity will be maintained at low-to-moderate intensity corresponding to 9–13 on the Borg Rating of Perceived Exertion scale. Adherence will be monitored using self-reported activity diaries and periodic telephone follow-up. Adherence will be defined as completion of at least 80% of prescribed exercise sessions throughout the intervention period. 109
Control Group Standard care Not applicable 6 months Participants in the control group will receive standard hypertension care only, including pharmacologic treatment, lifestyle counselling, dietary advice, and routine clinic follow-up in accordance with institutional hypertension management protocols. 109 Active-Treatment of Control Group
ELIGIBILITY CRITERIA
List inclusion criteria List exclusion criteria Age Category Minimum age Maximum age Gender
1. Be adults aged 18–60 years. 2. Have a documented diagnosis of hypertension for at least three months prior to recruitment. 3. Be engaged in a desk-based occupation involving predominantly seated work for at least 8 hours daily. 4. Be on stable anti hypertensive treatment for at least four weeks prior to enrollment. 5. Provide written informed consent. 1. Have severe hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg). 2. Have a recent cardiovascular event such as stroke or myocardial infarction within the preceding six months. 3. Have severe musculoskeletal, neurological, or mobility-limiting disorders that impair exercise participation. 4. Are pregnant. 5. Participate in structured moderate-to-vigorous physical activity exceeding 150 minutes weekly. 6. Have severe respiratory disease, uncontrolled arrhythmias, or any medical condition associated with exercise intolerance. Adult: 18 Year(s)-44 Year(s),Middle Aged: 45 Year(s)-64 Year(s) 18 Year(s) 60 Year(s) Both
ETHICS APPROVAL
Has the study received appropriate ethics committee approval Date the study will be submitted for approval Date of approval Name of the ethics committee
Yes 05/06/2026 Edo State University Teaching Hospital Research and Ethics Committee
Ethics Committee Address
Street address City Postal code Country
Old Igarra Road, Auchi, Edo State. Auchi 320001 Nigeria
OUTCOMES
Type of outcome Outcome Timepoint(s) at which outcome measured
Primary Outcome • Mean change in systolic blood pressure from baseline to 6 months. 3 months and 6 months post intervention
Secondary Outcome • Mean change in diastolic blood pressure, • Proportion of participants achieving blood pressure control, • Changes in BMI, • Changes in waist circumference and waist-to-hip ratio, • Adherence to the chair-based exercise programme. 3 months and 6 months post intervention
RECRUITMENT CENTRES
Name of recruitment centre Street address City Postal code Country
Department of Family Medicine Edo State University Teaching Hospital Old Igarra Road, Auchi 320001 Nigeria
FUNDING SOURCES
Name of source Street address City Postal code Country
Tijani Idris Ahmad Oseni Old Igarra Road, Auchi, Edo State. Auchi 320001 Nigeria
SPONSORS
Sponsor level Name Street address City Postal code Country Nature of sponsor
Primary Sponsor Society of Lifestyle Medicine of Nigeria SOLONg Department of Family Medicine, Lagos State University Teaching Hospital, Ikeja Nigeria Charities/Societies/Foundation
COLLABORATORS
Name Street address City Postal code Country
Dr. Francisca Atte Isuo Livingwell Consultancy Ltd, Port Harcourt Nigeria
Dr. Korubo Bernadette Centre for Excellence in Public Health, University of Port Harcourt Port Harcourt Nigeria
Dr. Oluwadamilola Blessing Elemile Department of Family Medicine, Redeemers Medical Centre, Mowe Ogun State Nigeria
Dr. Safiya Yahaya Kongoila Society of Lifestyle Medicine of Nigeria Abuja Nigeria
Dr. Moyosore Taiwo Makinde Department of Family Medicine, Lagos State University Teaching Hospital Ikeja Nigeria
Dr Ifeoma N Monye Brookfields Clinics Centre for Lifestyle Medicine Abuja Nigeria
CONTACT PEOPLE
Role Name Email Phone Street address
Principal Investigator Tijani Idris Ahmad Oseni oseni.tijani@edouniversity.edu.ng 2348036281897 Department of Family Medicine, Edo State University Teaching Hospital,
City Postal code Country Position/Affiliation
Auchi Nigeria Associate Professor of Family Medicine Edo State University Iyamho Nigeria
Role Name Email Phone Street address
Public Enquiries Tijani Idris Ahmad Oseni oseni.tijani@edouniversity.edu.ng 2348036281897 Department of Family Medicine Edo State University Teaching Hospital
City Postal code Country Position/Affiliation
Auchi Nigeria Associate Professor of Family Medicine Edo State University Iyamho Nigeria
Role Name Email Phone Street address
Scientific Enquiries Tijani Idris Ahmad Oseni oseni.tijani@edouniversity.edu.ng 2348036281897 Department of Family Medicine, Edo State University Teaching Hospital
City Postal code Country Position/Affiliation
Auchi Nigeria Associate Professor of Family Medicine Edo State University Iyamho Nigeria
REPORTING
Share IPD Description Additional Document Types Sharing Time Frame Key Access Criteria
Yes Individual Participant Data (IPD) including raw data that has been de-identified and additional documents used in the study will be shared after de-identification. Informed Consent Form,Study Protocol IPD documents will be available from the time of completion of the study to upto two years after the completion of the study IPD will be controlled and only provided on request to study participants and important stakeholders like trial registry and journal editor.
URL Results Available Results Summary Result Posting Date First Journal Publication Date
No
Result Upload 1: Result Upload 2: Result Upload 3: Result Upload 4: Result Upload 5:
Result URL Hyperlinks Link To Protocol
Result URL Hyperlinks
Changes to trial information
Section Name Field Name Date Reason Old Value Updated Value
Trial Information Public title 31/07/2026 PACTR Admin EFFECTIVENESS OF A STRUCTURED CHAIR-BASED EXERCISE INTERVENTION ON BLOOD PRESSURE CONTROL AMONG DESK-BASED WORKERS WITH HYPERTENSION IN SOUTHERN NIGERIA: A RANDOMIZED CONTROLLED TRIAL Effectiveness of a structured chair-based exercise intervention on blood pressure control among desk-based workers with hypertension in southern Nigeria: a randomized controlled trial
Section Name Field Name Date Reason Old Value Updated Value
Intervention Intervention List 30/05/2026 Group removed from the intervention name as it is not part of the intervention name Experimental Group, Chair based exercise group, Each exercise will be performed for one minute, giving a total exercise duration of approximately five minutes per session. Participants will be instructed to perform the exercise routine every 60 minutes during working hours over an average 8-hour workday, amounting to approximately 40 minutes of daily physical activity., The study intervention will last for 3 months while participants will be followed up for six months, with assessments conducted at baseline, 3 months, and 6 months., Participants in the intervention arm will receive standard hypertension care in addition to a structured chair-based exercise programme designed for workplace implementation. The exercise programme will consist of five chair-based exercises: • Seated marching • Knee extensions • Seated calf raises • Seated torso rotations • Seated jumping jacks Each exercise will be performed for one minute, giving a total exercise duration of approximately five minutes per session. Participants will be instructed to perform the exercise routine every 60 minutes during working hours over an average 8-hour workday, amounting to approximately 40 minutes of daily physical activity. The intervention will be delivered through: 1. An initial supervised demonstration session, 2. Printed instructional materials, 3. Weekly reminder messages via WhatsApp or SMS, 4. Monthly reinforcement sessions during clinic visits. Exercise intensity will be maintained at low-to-moderate intensity corresponding to 9–13 on the Borg Rating of Perceived Exertion scale. Adherence will be monitored using self-reported activity diaries and periodic telephone follow-up. Adherence will be defined as completion of at least 80% of prescribed exercise sessions throughout the intervention period. , 109, Experimental Group, Chair based exercise, Each exercise will be performed for one minute, giving a total exercise duration of approximately five minutes per session. Participants will be instructed to perform the exercise routine every 60 minutes during working hours over an average 8-hour workday, amounting to approximately 40 minutes of daily physical activity., The study intervention will last for 3 months while participants will be followed up for six months, with assessments conducted at baseline, 3 months, and 6 months., Participants in the intervention arm will receive standard hypertension care in addition to a structured chair-based exercise programme designed for workplace implementation. The exercise programme will consist of five chair-based exercises: • Seated marching • Knee extensions • Seated calf raises • Seated torso rotations • Seated jumping jacks Each exercise will be performed for one minute, giving a total exercise duration of approximately five minutes per session. Participants will be instructed to perform the exercise routine every 60 minutes during working hours over an average 8-hour workday, amounting to approximately 40 minutes of daily physical activity. The intervention will be delivered through: 1. An initial supervised demonstration session, 2. Printed instructional materials, 3. Weekly reminder messages via WhatsApp or SMS, 4. Monthly reinforcement sessions during clinic visits. Exercise intensity will be maintained at low-to-moderate intensity corresponding to 9–13 on the Borg Rating of Perceived Exertion scale. Adherence will be monitored using self-reported activity diaries and periodic telephone follow-up. Adherence will be defined as completion of at least 80% of prescribed exercise sessions throughout the intervention period. , 109,
Section Name Field Name Date Reason Old Value Updated Value
Intervention Intervention List 30/05/2026 group is not part of the intervention hence removed Control Group, Standard care group, Not applicable, 6 months, Participants in the control group will receive standard hypertension care only, including pharmacologic treatment, lifestyle counselling, dietary advice, and routine clinic follow-up in accordance with institutional hypertension management protocols., 109, Active-Treatment of Control Group Control Group, Standard care, Not applicable, 6 months, Participants in the control group will receive standard hypertension care only, including pharmacologic treatment, lifestyle counselling, dietary advice, and routine clinic follow-up in accordance with institutional hypertension management protocols., 109, Active-Treatment of Control Group
Section Name Field Name Date Reason Old Value Updated Value
Outcome OutCome List 30/05/2026 time point clarified to include post intervention Primary Outcome, • Mean change in systolic blood pressure from baseline to 6 months. , 3 months and 6 months Primary Outcome, • Mean change in systolic blood pressure from baseline to 6 months. , 3 months and 6 months post intervention
Section Name Field Name Date Reason Old Value Updated Value
Outcome OutCome List 30/05/2026 post intervention included on the time point to clarify it Secondary Outcome, • Mean change in diastolic blood pressure, • Proportion of participants achieving blood pressure control, • Changes in BMI, • Changes in waist circumference and waist-to-hip ratio, • Adherence to the chair-based exercise programme., 3 months and 6 months Secondary Outcome, • Mean change in diastolic blood pressure, • Proportion of participants achieving blood pressure control, • Changes in BMI, • Changes in waist circumference and waist-to-hip ratio, • Adherence to the chair-based exercise programme., 3 months and 6 months post intervention
Section Name Field Name Date Reason Old Value Updated Value
Ethics Ethics List 05/07/2026 Ethical approval received FALSE, Edo State University Teaching Hospital Research and Ethics Committee, Old Igarra Road, Auchi, Edo State., Auchi, 320001, Nigeria, 21 May 2026, , +2348036281897, edsuth@edouniversity.edu.ng, TRUE, Edo State University Teaching Hospital Research and Ethics Committee, Old Igarra Road, Auchi, Edo State., Auchi, 320001, Nigeria, 21 May 2026, 05 Jun 2026, +2348036281897, edsuth@edouniversity.edu.ng, 41390_38626_4737.pdf
Section Name Field Name Date Reason Old Value Updated Value
Funding Source FundingSources List 30/05/2026 Actual name of principal investigator written as source of funding Self Funded, Old Igarra Road, Auchi, Edo State., Auchi, 320001, Nigeria, Self Funded, Tijani Idris Ahmad Oseni, Old Igarra Road, Auchi, Edo State., Auchi, 320001, Nigeria, Self Funded,
Section Name Field Name Date Reason Old Value Updated Value
Reporting IPD description 30/05/2026 IPD description reviewed to include raw data after de-identification Individual Participant Data (IPD) will be stored in password protected files accessible only to the researcher Individual Participant Data (IPD) including raw data that has been de-identified and additional documents used in the study will be shared after de-identification.
Section Name Field Name Date Reason Old Value Updated Value
Reporting IPD-Sharing time frame 30/05/2026 The time from from start to end specified IPD will be shared to participants on request and will be available for upto two years after the completion of the study IPD documents will be available from the time of completion of the study to upto two years after the completion of the study